ٹائروسین · N-acetyl-L-tyrosine
Weak evidence
Helps thinking under stress and sleep loss. No good evidence it treats depression.
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An amino acid the body uses to make dopamine, adrenaline and thyroid hormones.
The decent evidence is narrow and specific: it appears to protect mental performance during acute stress, cold or sleep deprivation - military and shift-work studies. For depression itself, trials have been negative or inconclusive. Marketed for motivation on the strength of the mechanism rather than results.
Studies of stress performance used 100 to 150 mg per kg of body weight, which is much more than a typical capsule.
Recorded because a person who has decided to try something will find a number somewhere, and a forum's number is worse than a trial's. It is not a recommendation, and the right amount for you depends on things only a doctor who knows your history can weigh.
Avoid with MAOI antidepressants - a hypertensive crisis risk. Care with overactive thyroid or thyroid medication, since tyrosine is a thyroid hormone building block. Can cause restlessness and insomnia.
Sold mainly in gym and nootropic shops rather than pharmacies.
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